Kazuho Abe Selected Research

CNB 001

1/2020	The Synthetic Curcumin Derivative CNB-001 Attenuates Thrombin-Stimulated Microglial Inflammation by Inhibiting the ERK and p38 MAPK Pathways.
1/2018	CNB-001, a synthetic pyrazole derivative of curcumin, suppresses lipopolysaccharide-induced nitric oxide production through the inhibition of NF-κB and p38 MAPK pathways in microglia.
8/2012	Suppressive effects of a pyrazole derivative of curcumin on airway inflammation and remodeling.

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Kazuho Abe Research Topics

Disease

8	Alzheimer Disease (Alzheimer's Disease) 01/2018 - 01/2003
3	Inflammation (Inflammations) 01/2020 - 01/2012
2	Amyloid Plaque 01/2014 - 02/2010
2	Asthma (Bronchial Asthma) 08/2012 - 02/2004
2	Cognitive Dysfunction 01/2011 - 02/2010
1	Wounds and Injuries (Trauma) 01/2020
1	Airway Remodeling 08/2012
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2011
1	Memory Disorders (Memory Loss) 10/2006
1	Allergic Rhinitis 05/2006

Drug/Important Bio-Agent (IBA)

5	Amyloid beta-PeptidesIBA 01/2011 - 01/2003
4	Proteins (Proteins, Gene)FDA Link 01/2014 - 02/2004
3	CurcuminIBA 01/2020 - 08/2012
3	CNB 001IBA 01/2020 - 08/2012
3	Pharmaceutical PreparationsIBA 03/2012 - 10/2008
2	pyrazoleIBA 01/2018 - 08/2012
2	Amyloid (Amyloid Fibrils)IBA 01/2014 - 02/2010
2	Messenger RNA (mRNA)IBA 08/2012 - 02/2004
2	fisetinIBA 10/2008 - 10/2006
2	Biological ProductsIBA 10/2008 - 10/2006
2	Glutamic Acid (Glutamate)FDA Link 07/2003 - 01/2003
1	Nitric Oxide Synthase (NO Synthase)IBA 01/2020
1	p38 Mitogen-Activated Protein KinasesIBA 01/2020
1	Serine Proteases (Serine Protease)IBA 01/2020
1	2-f)quinazoline-1,3-diamine N3- cyclopropyl- 7- ((4- (1- methylethyl)phenyl)methyl)- 7H- pyrrolo(3IBA 01/2020
1	PAR-1 ReceptorIBA 01/2020
1	Thrombin FDA Link 01/2020
1	Interleukin-6 (Interleukin 6)IBA 08/2012
1	Protease Inhibitors (Protease Inhibitor)IBA 08/2012
1	Serine (L-Serine)FDA Link 08/2012
1	VimentinIBA 08/2012
1	Cadherins (E-Cadherin)IBA 08/2012
1	Interleukin-13IBA 08/2012
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2012
1	ProstaglandinsIBA 01/2012
1	LigandsIBA 01/2011
1	Amino Acids FDA Link 02/2010
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 02/2010
1	Peptides (Polypeptides)IBA 02/2010
1	AntigensIBA 05/2006
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 05/2006
1	OvalbuminIBA 05/2006
1	Protein Isoforms (Isoforms)IBA 05/2006
1	CytokinesIBA 02/2004
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2004
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 07/2003

Therapy/Procedure

1	Therapeutics 02/2010